Another structure quiz answers

Here are the answers to another structure quiz

1, Chloroform – note the simple hydrocarbon structure in common with many of the volatile anaesthetic agents, including the next two below

Chloroform

2. Isoflurane

iso-structure

3. Enflurane – note that isoflurane and enflurane are structural isomers of each other. They have the same atoms, rearranged in a different order. What differences due the change in arrangement of the atoms make to the properties of these two drugs?

medchem1ic_Enflurane_full_498_229__0_native

4. Codeine – the methylated form of the drug below. Demethylation by CYP2D6 results in conversion to morphine

1200px-Codein_-_Codeine.svg

5. Morphine – naturally occurring phenanthrene

1200px-Morphin_-_Morphine.svg

6. Tramadol – can you find the structural similarity to codeine, which results in the two drugs being metabolised at the same enzyme?

150px-(1S,2S)-Tramadol_gespiegelt.svg

7. Naloxone – did anyone get this one. Interestingly all conventional mu receptor antagonists are structural analogues of morphine, with a bulky substitution the N17 position.

naloxone.jpg.pagespeed.ce.Q70R1-33LY-2

8. Tubocurarine – purely of historic interest. Did some of you pick the class of drug based on the quaternary ammonium and the isoquinoline  structure?Tubocurarine.svg

9. Glycopyrrolate – another drug working a the ACh receptor. Look for similarities in structure with the drug above. How does glycopyrrolate differ from atropine structurally? What difference does this make in clinical practice?

g-386

10. Neostigmine – what features help it associate with the AChE? Can you find the carbamyl ester?

g-590

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